Propa 15 Tablet

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Generic : Propantheline Bromide
Therapeutic : Propantheline Bromide


Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle. It also has a direct relaxing effect on smooth muscle. Propantheline is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Propantheline inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.


Action Propantheline Bromide is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).



1. Propa is indicated as an adjunctive therapy in the treatment of peptic ulcer (gastric and duodenal) and for the relief of the symptoms of gastritis.

2. Propa is also indicated for spastic and inflammatory disease of GI and urinary tracts such as the symptomatic treatment of the irritable bowel syndrome (irritable colon, spastic colon, mucous colitis, acute enterocolitis, nervous diarrhoea and functional gastrointestinal disorders). Other indications include renal colic, hyperhidrosis, as adjunctive therapy in ulcerative colitis, diverticulitis, cholecystitis, pancreatitis and for certain gastrointestinal diagnostic procedures (Duodenography).

3. Control of salivation and enuresis.

4. Second-line therapy for urinary incontinence.


Dosage & Administration

Dosage should be individualized. The usual initial adult dosage is 15 mg (One tablet) 30 minutes before each meal and 30 mg at bedtime (i.e., 75 mg daily). Dosage should be carefully titrated until therapeutic effect is achieved.The maximum daily dosage should not exceed 120 mg. Subsequent dosage adjustments should be made according to the patient's individual response and tolerance.

For other indications, the dose is 15 to 30 mg 4 times daily.


Side Effects

With the exception of fewer effects on the eye and the CNS, Propantheline can be expected to have a similar adverse reaction profile as Atropine (dry mouth, dry eyes, urinary hesitancy, tachycardia, constipation etc).


Use in Special Group:


Safety and efficacy of Propantheline Bromide in children have not been established.


Caution should also be exercised in elderly patients because of the possibility of inducing urinary retention. Urinary retention may be avoided if these patients are advised to micturate at the time of taking medication. Caution should also be exercised in elderly patients due to the danger of precipitating undiagnosed glaucoma.


Safe use of Propa in pregnancy has not been established.


As many agents are excreted in human milk, caution should be exercised when Propantheline Bromide is administered to a breast feeding woman. Suppression of lactation may occur with anticholinergic agents.



The medicine is contraindicated in patients with:

•Hypersensitivity to Propantheline Bromide or other anticholinergic agents or any of the ingredients in Propa tablet.

•Tachycardia secondary to cardiac insufficiency or thyrotoxicosis.

•Glaucoma, since mydriasis is to be avoided.

•Obstructive disease of the gastrointestinal tract (pyloroduodenal stenosis, achalasia, paralytic ileus etc).

•Obstructive uropathy (prostatism).

•Intestinal atony of elderly or debilitated patients.



Take Propantheline tablet at least an hour before food or on an empty stomach.

If you miss a dose of Propantheline, take it as soon as possible. If it is almost time for your next dose, then skip the missed dose and continue taking at the usual times.

This medicine may cause drowsiness and blurred vision. If affected do not drive or operate machinary.

Propantheline can cause a dry mouth. For relief, try sucking sugar-free sweets, pieces of ice or chewing sugar-free gum.


Drug Interaction:

Antacids or Absorbent Antidiarrhoeals: May reduce the absorption of Propantheline Bromide, therefore resulting in a reduction of its therapeutic effectiveness. Therefore, take two to three hours apart from doses of Propantheline Bromide.

Anticholinergics: May delay absorption of other medication given concomitantly.

Antimyasthenics: Concurrent use with Propantheline Bromide may further reduce intestinal motility.



Keep away from light, moisture and store below 300 C. Keep out of the reach children.


Commercial Packaging:

Propa 15 Tablet: Box Containing 3 x 10 tablets in blister pack

Download Product Manual


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