Azapin 15 Tablet
Generic : Mirtazapine
Therapeutic : Mirtazapine
Description :
Azapin (Mirtazapine) is a tetracyclic antidepressant belongs to piperazine-azepine group of compounds. The mechanism of action is unknown. Studies suggest that Mirtazapine enhances central noradrenergic and serotonergic activity. Mirtazapine acts as an antagonist at central presynaptic alpha-2 adrenergic inhibitory auto receptors and heteroreceptors that results in an increased central noradrenergic and serotonergic activity.
Indications :
Azapin (Mirtazapine) is indicated for the treatment of depression.
Dosage and Administration :
Adult: Initially, 15 mg daily; may be increased gradually depending on clinical response. Change dose at intervals of at least 1-2 weeks. Usual effective dose: 15-45 mg daily given as single dose, preferably at bedtime, or in 2 divided doses. It can be taken with or without food.
Children: Safety and efficacy not established.
Side Effects :
The most commonly reported adverse effects with Mirtazapine are increase in appetite, weight gain, edema, drowsiness or sedation, dizziness, headache etc.
Use in Pregnancy &Lactation :
Mirtazapine should not be used during pregnancy and lactation.
Contraindications :
Mirtazapine is contraindicated in patients with hypersensitivity. Do not use with or within 2 weeks of stopping an MAOI; at least 1 week should elapse between discontinuing Mirtazapine and initiating any drug which may provoke a serious reaction (e.g. phenelzine).
Precautions :
Mirtazapine should be used cautiously in patients with epilepsy or history of seizure, history of mania /hypomania, patients with hepatic or renal impairment; cardiac disorders e.g. conduction disturbances, angina pectoris, recent MI, Hypotension, DM, psychoses, history of bipolar disorder. Stop treatment if jaundice develops. Monitor patient for signs of bone marrow depression or suicidal tendency. Avoid abrupt withdrawal. May impair ability to drive or operate machinery.
Drug Interaction :
Mirtazapine potentiates sedative effects with alcohol or benzodiazepines, increases plasma levels with potent CYP3A4 inhibitors (e.g. HIV-protease inhibitors, azole antifungals including ketoconazole, erythromycin, nefazodone), reduces plasma levels with carbamazepine and other inducers of CYP3A4 and increases bioavailability with cimetidine.
Storage :
Keep away from light, moisture and store below 30o C. Keep out of reach of children.
Commercial Pack :
Azapin 15 Tablet : Each box contains 3 X 10 tablets, in blister pack.
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