Ciproaid-500mg
Generic : Ciprofloxacin
Therapeutic : Ciprofloxacin
Composition :
Ciproaid 500 Tablet: Each film coated tablet contains Ciprofloxacin Hydrochloride USP equivalent to 500 mg of Ciprofloxacin.
Ciproaid Pellets for Suspension: After reconstitution, each 5 ml suspension contains Ciprofloxacin Hydrochloride USP equivalent to Ciprofloxacin 250 mg.
Description :
Ciprofloxacin is a synthetic quinolone anti-infective agent. It has broad spectrum of activity. It is active against most gram-negative aerobic bacteria including
Enterobacteriaceae and Pseudomonas aeruginosa. Ciprofloxacin is also active against gram-positive aerobic bacteria including penicillinase producing, non-penicillinase producing and methicillin resistant Staphylococci, although many strains of Streptococci are relatively resistant to the drug. The antibacterial action of Ciprofloxacin results from interference with the enzyme DNA gyrase needed for the synthesis of bacterial DNA. Following oral administration, it is rapidly and well absorbed from the GI tract. It is widely distributed into body tissues and fluids. The half-life is about 3.5 hours. About 30% to 50% of an oral dose of Ciprofloxacin is excreted in the urine within 24 hours as unchanged drug and biologically active metabolites.
Indications :
- Urinary tract infection
- Chronic bacterial prostatitis
- Lower respiratory tract infection
- Acute sinusitis
- Skin and skin structure infection
- l Bone and joint infection
- Intra-abdominal infection
- Infectious diarrhea
- Typhoid fever
- Urethral and cervical infection
- Anthrax
- Surgical prophylaxis
Dosage and Administration :
Side effects :
Side effects include nausea and other gastrointestinal disturbances, headache, dizziness and skin rashes. Crystalluria has occurred with high doses.
Use in special group :
Pregnancy and lactation: Not to be used in pregnancy and nursing stage.
Pediatric use: Though not recommended for the children, a dosage of 7.5-15 mg/kg/day in two divided doses can be given where benefit outweighs risk.
Contraindications :
Patients with a history of hypersensitivity to Ciprofloxacin or to other quinolones.
Precautions :
It should be used with caution in patients with suspected or known CNS disorders such as arteriosclerosis or epilepsy or other factors which predispose to seizures and convulsion.
Drug Interaction :
Absorption of Ciprofloxacin is reduced by antacid and calcium salts. It reduces antiplatelet effect of clopidogrel.
Storage :
Store in a cool and dry place, away from light. Keep out of the reach of children.
Commercial Pack :
Ciproaid 500 Tablet: Each box contains 2 x 10 tablets in Alu-PVDC blister
pack.
Ciproaid Pellets for Suspension: Each bottle contains Ciprofloxacin pellets for preparation of 60 ml suspension.
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