Etorica 60 Tablet
Generic : Etoricoxib
Therapeutic : Etoricoxib
Description:
Etorica is the preparation of Etoricoxib. It is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic activities in animal models. It is a potent, orally active, highly selective cyclooxygenase-2 (COX-2) inhibitor within and above the clinical dose range. COX-2 has been shown to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation and fever. Selective inhibition of COX-2 by Etorica decreases these clinical signs and symptoms with decreased GI toxicity and without effects on platelet function.
Indications:
l Pain and inflammation in osteoarthritis, rheumatoid arthritis and other chronic musculoskeletal disorders
l The management of ankylosing spondylitis
l Acute gout
l Pain of dysmenorrhoea and
l Pain following dental surgery.
Dosage & Administration:
Adult and adolescent over 16 years:
l In case of osteoarthritis, dysmenorrhoea, chronic musculoskeletal disorders, 60 mg once daily.
l In case of rheumatoid arthritis and ankylosing spondylitis, 90 mg once daily.
l In case of pain following dental surgery, acute gout, 120 mg once daily.
l Safety and effectiveness of Etoricoxib in paediatric patients have not been established.
Side Effects:
Side effects may include dry mouth, taste disturbance, mouth ulcers, flatulence, constipation, appetite and weight changes, chest pain, fatigue, paraesthesia, influenza-like syndrome, myalgia.
Use in special group:
Pregnancy: As with other drugs known to inhibit prostaglandin synthesis, use of it should be avoided in late pregnancy because it may cause premature closure of the ductusarteriosus. It should be used during the first two trimesters of pregnancy only if the potential benefit justifies the potential risk to the foetus.
Lactation: It is not known whether this drug is excreted in human milk.
Contraindications:
It is contraindicated in patients with hypersensitivity to any component of this product, patients with inflammatory bowel disease and severe congestive heart failure.
Precautions:
In patients with advanced renal disease, treatment with Etoricoxib is not recommended. Clinical experience in patients with estimated creatinine clearance of <30 ml/min is very limited. If therapy with Etoricoxib must be initiated in such patients, close monitoring of the patient's renal function is advisable. Caution should be used when initiating treatment in patients with considerable dehydration. It is advisable to rehydrate patients prior to starting therapy. The possibility of fluid retention, oedema or hypertension should be taken into consideration when it is used in patients with pre-existing oedema, hypertension, or heart failure. Independent of treatment, patients with a prior history of GI perforation, ulcers and bleeding (PUB) and patients greater than 65 years of age are known to be at a higher risk for a PUB. A patient with symptoms and/or signs suggesting liver dysfunction, or in whom an abnormal liver function test has occurred, should be evaluated for persistently abnormal liver function tests. If persistently abnormal liver function tests (three times the upper limit of normal) are detected, it should be discontinued. It should be used with caution in patients who have previously experienced acute asthmatic attacks, urticaria or rhinitis, which were precipitated by salicylates or non-selective cyclooxygenase inhibitors. It may mask fever, which is a sign of infection. The physician should be aware of this when using it in patients being treated for infection.
Drug Interaction:
At high dose, Etoricoxib may have interaction with Warfarin, Methotrexate, ACE inhibitors, Lithium & Aspirin.
Storage :
Keep away from light & moisture and store below 300 C temperature. Keep out of reach of children.
Commercial Pack:
Etorica 60 Tablet : Each box containing 3x10 Tablets, in Alu-PVDC blister pack.
Etorica 90 Tablet : Each box containing 3x10 Tablets, in Alu-PVDC blister pack.
Etorica 120 Tablet : Each box containing 2x10 Tablets, in Alu-PVDC blister pack.
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